Over the last few years, the development of 3D printing has enabled numerous advances in research. This type of printing technology opens a vast array of possibilities in analytical chemistry, and more particularly in the field of flow analysis. Ease of fabrication and flexibility of this technology has led to the development of a new type of system for the determination of lead in natural waters. This device is composed of three units: a column for selective retention of lead, a mixing coil and a microfluidic cell for UV-Vis spectroscopy. The final goal is to get a fast system which can be used on site, with a low limit of detection and quantification.